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Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells
Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 341-346 doi: 10.1007/s11684-009-0067-9
关键词: human cervical cancer cells apoptosis phosphatidylinositol 3-kinase (PI3K)/Akt FLICE-like inhibitory protein
Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma
《医学前沿(英文)》 2018年 第12卷 第6期 页码 688-696 doi: 10.1007/s11684-018-0662-8
Xiao Ke Qing (XKQ) granule has been clinically used to treat type 2 diabetes mellitus (T2DM) for 10 years in Chinese traditional medication. However, its mechanisms against hyperglycemia remain poorly understood. This study aims to investigate XKQ mechanisms on diabetes and diabetic liver disease by using the KKAy mice model. Our results indicate that XKQ can significantly reduce food and water intake. XKQ treatment also remarkably decreases both the fasting blood glucose and blood glucose in the oral glucose tolerance test. Additionally, XKQ can significantly decrease the serum alanine aminotransferase level and liver index and can alleviate the fat degeneration in liver tissues. Moreover, XKQ can ameliorate insulin resistance and upregulate the expression of IRS-1, PI3K (p85), p-Akt, and GLUT4 in the skeletal muscle of KKAy mice. XKQ is an effective drug for T2DM by ameliorating insulin resistance and regulating the PI3K/Akt signaling pathway in the skeletal muscle.
关键词: XKQ type 2 diabetes mellitus KKAy mice PI3K/Akt pathway diabetic liver disease
LI Yanhua, BI Zhigang
《医学前沿(英文)》 2007年 第1卷 第1期 页码 79-86 doi: 10.1007/s11684-007-0016-4
RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway
《医学前沿(英文)》 2023年 第17卷 第1期 页码 143-155 doi: 10.1007/s11684-022-0929-y
Mingyu Pi, Xiaodeng Wang, Dingke Zhang, Shuxia Wang, Shijian Chen
《化学科学与工程前沿(英文)》 2018年 第12卷 第3期 页码 425-432 doi: 10.1007/s11705-018-1726-7
Self-standing porous WP2 nanosheet arrays on carbon fiber cloth (WP2 NSs/CC) were synthesized and used as a 3D flexible hydrogen evolution electrode. Because of its 3D porous nanoarray structure, the WP2 NSs/CC exhibits a remarkable catalytic activity and a high stability. By using the experimental measurements and first-principle calculations, the underlying reasons for the excellent catalytic activity were further explored. Our work makes the present WP2 NSs as a promising electrocatalyst for hydrogen evolution and provides a way to design and fabricate efficient hydrogen evolution electrodes through 3D porous nano-arrays architecture.
关键词: WP2 nanosheet arrays hydrogen evolution electrocatalyst flexible electrode
Fatigue crack growth simulations of 3-D linear elastic cracks under thermal load by XFEM
K. YADAV
《结构与土木工程前沿(英文)》 2015年 第9卷 第4期 页码 359-382 doi: 10.1007/s11709-015-0304-z
Comparison study on strategies to prepare nanocrystalline Li
Qiang XIAO, Xiaodan TANG, Yefeng LIU, Yijun ZHONG, Weidong ZHU
《化学科学与工程前沿(英文)》 2013年 第7卷 第3期 页码 297-302 doi: 10.1007/s11705-013-1346-1
关键词: CO2 capture Li2ZrO3 K-doped Li2ZrO3 citrate starch freeze-drying technique
Acetyl salicylic acid attenuates cardiac hypertrophy through Wnt signaling
null
《医学前沿(英文)》 2015年 第9卷 第4期 页码 444-456 doi: 10.1007/s11684-015-0421-z
Ventricular hypertrophy is a powerful and independent predictor of cardiovascular morbid events. The vascular properties of low-dose acetyl salicylic acid (aspirin) provide cardiovascular benefits through the irreversible inhibition of platelet cyclooxygenase 1; however, the possible anti-hypertrophic properties and potential mechanism of aspirin have not been investigated in detail. In this study, healthy wild-type male mice were randomly divided into three groups and subjected to transverse aortic constriction (TAC) or sham operation. The TAC-operated mice were treated with the human equivalent of low-dose aspirin (10 mg·kg−1·d−1); the remaining mice received an equal amount of phosphate buffered saline with 0.65% ethanol, which was used as a vehicle. A cardiomyocyte hypertrophy model induced by angiotensin II (10 nmol·L−1) was treated with the human equivalent of low (10 or 100 µmol·L−1) and high (1000 µmol·L−1) aspirin concentrations in plasma. Changes in the cardiac structure and function were assessed through echocardiography and transmission electron microscopy. Gene expression was determined through RT-PCR and western blot analysis. Results indicated that aspirin treatment abrogated the increased thickness of the left ventricular anterior and posterior walls, the swelling of mitochondria, and the increased surface area in in vivo and in vitro hypertrophy models. Aspirin also normalized the upregulated hypertrophic biomarkers, β-myosin heavy chain (β-MHC), atrial natriuretic peptide (ANP), and b-type natriuretic peptide (BNP). Aspirin efficiently reversed the upregulation of β-catenin and P-Akt expression and the TAC- or ANG II-induced downregulation of GSK-3β. Therefore, low-dose aspirin possesses significant anti-hypertrophic properties at clinically relevant concentrations for anti-thrombotic therapy. The downregulation of β-catenin and Akt may be the underlying signaling mechanism of the effects of aspirin.
YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng
《化学科学与工程前沿(英文)》 2007年 第1卷 第4期 页码 343-348 doi: 10.1007/s11705-007-0062-0
关键词: 4-butanediol 2-methoxyethylenoxy consistent oxetane-derived copolymer
Control of peak pressures of an HCCI engine under varying swirl and operating parameters
AMBA PRASAD RAO,K. MADHU MURTHY
《能源前沿(英文)》 2016年 第10卷 第3期 页码 337-346 doi: 10.1007/s11708-016-0401-2
关键词: HCCI engine ECFM-3Z Swirl ratio peak pressures engine speed piston bowl geometry
Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice
ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong
《医学前沿(英文)》 2008年 第2卷 第1期 页码 95-99 doi: 10.1007/s11684-008-0017-y
关键词: development challenging rSj14-3-3 resistance cultural supernatant
《医学前沿(英文)》 2023年 第17卷 第1期 页码 119-131 doi: 10.1007/s11684-022-0949-7
关键词: GDF15 esophageal squamous cell carcinoma chemoresistance cellular metabolism TGFBR2 AKT
作为免疫疗法靶点的FOXP3及其辅因子 Review
Yasuhiro Nagai,Lian Lam,Mark I. Greene,Hongtao Zhang
《工程(英文)》 2019年 第5卷 第1期 页码 115-121 doi: 10.1016/j.eng.2019.01.001
叉头框蛋白P3(FOXP3)是调节性T细胞(Tregs)的一个主要调节因子,调节性T细胞是能抑制抗原特异性免疫反应的T 细胞亚群,在增强宿主耐受性和维持免疫平衡方面发挥着重要作用。众所周知,FOXP3 与多种蛋白质形成复合物,并能通过乙酰化、磷酸化、泛素化和甲基化等各种翻译后修饰(PTM)进行调节。因此,翻译后修饰可改变FOXP3 的稳定性及其调节基因表达的能力,并最终影响调节性T细胞活性。虽然FOXP3 自身并非理想的药物靶点,但脱乙酰酶、乙酰转移酶、激酶和其他可调节FOXP3 的翻译后修饰的酶均为调控FOXP3 和调节性T细胞活性的潜在靶点。但FOXP3 并非这些酶的唯一底物;因此,当使用相关抑制剂时,必须考虑是否存在有害的“FOXP3脱靶”副作用。
关键词: 调节性T细胞 叉头框蛋白P3(FOXP3) 翻译后修饰 自体免疫 癌症
《医学前沿(英文)》 doi: 10.1007/s11684-023-1003-0
关键词: Lipin3 Lipin1 hypertriglyceridemia obesity mitochondrial dysfunction
Kan Wang, Chia-Che Ho, Chuck Zhang, Ben Wang
《工程(英文)》 2017年 第3卷 第5期 页码 653-662 doi: 10.1016/J.ENG.2017.05.013
标题 作者 时间 类型 操作
Effects of phosphatidylinositol 3-kinase inhibitor on human cervical carcinoma cells
Yuan ZHANG MD , Xiaoyan ZHANG MM , Yanhui LI MM , Xuan DU MM , Zehua WANG MD, PhD , Hongbo WANG MD ,
期刊论文
Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway
Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma
期刊论文
Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway
LI Yanhua, BI Zhigang
期刊论文
A 3D porous WP2 nanosheets@carbon cloth flexible electrode for efficient electrocatalytic hydrogen evolution
Mingyu Pi, Xiaodeng Wang, Dingke Zhang, Shuxia Wang, Shijian Chen
期刊论文
Fatigue crack growth simulations of 3-D linear elastic cracks under thermal load by XFEM
K. YADAV
期刊论文
Comparison study on strategies to prepare nanocrystalline Li
Qiang XIAO, Xiaodan TANG, Yefeng LIU, Yijun ZHONG, Weidong ZHU
期刊论文
Synthesis of copolymers of 3-acryloyloxymethyl-3′-methyloxetane and 3-(2-(2-(2-Methoxyethylenoxy)ethylenoxy)ethylenoxy)-3′-methyloxetane and their ionic conductivity properties
YE Lin, ZHAO Yumei, FENG Zengguo, BAI Ying, WU Feng
期刊论文
Control of peak pressures of an HCCI engine under varying swirl and operating parameters
AMBA PRASAD RAO,K. MADHU MURTHY
期刊论文
Heterologous expression of signal protein 14-3-3 in and the subsequent immune response in mice
ZHENG Meijuan, SHEN Jilong, LUO Qingli, XU Yuanhong
期刊论文
GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal
期刊论文
Haploinsufficiency of Lipin3 leads to hypertriglyceridemia and obesity by disrupting the expression and
期刊论文